Research

As the national university, we champion and support innovative research that addresses the country’s most pressing challenges.

20 Jul 2023

UP Mindanao

Future solid waste management system in Davao City should prioritize plastic waste treatment

To reduce adverse environmental impact, municipal solid waste management (MSWM) practices in developed countries are adopted in developing countries without...

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19 Jul 2023

UP Los Baños

Pesticide residues were found in commonly consumed vegetables and those labeled “organic”

Pesticide residues on vegetables pose food safety concerns. In this study, an assay called the Rapid Bioassay for Pesticide Residues...

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19 Jul 2023

UP Diliman

Surface constraint approach optimizes the design and trajectory of solar sails that are constrained to move on surfaces

Solar sailing is a propulsion technology that uses the solar radiation pressure of the sun as a source for thrust....

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18 Jul 2023

UP Diliman

Studies on disasters can only be inclusive if scholars and practitioners “decolonize” themselves

The discussions on the decolonization of knowledge in disasters are not entirely new and have been the subject of inquiries...

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14 Jul 2023

UP Diliman

“Filipinized” system that aims to make online learning accessible to nursing students and teachers presented at international conference

The project “Development of a Filipinized Learning Management System” (FLMS), funded by the Emerging Interdisciplinary Research Program of the the...

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10 Jul 2023

UP Los Baños

Transgender poet reflects on what it means to live under the new presidency

Now is no longer the time for poets is a suite of three poems with the following titles: “To write
another...

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07 Jul 2023

UP Manila

Pilgrimage can help ease symptoms of depression and anxiety

Research by psychologists and other mental health professionals tries to identify effective ways to manage and prevent emotional turbulence, including...

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07 Jul 2023

UP Visayas

A study of Chavacano shows how linguistic prestige evolves with changes in society

Chavacano is the lone Spanish-based creole in Asia and is spoken in different parts of the Philippine archipelago. Among the...

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07 Jul 2023

UP Los Baños

The sentiments of political actors on social media are “carefully manufactured” and affect our sense of nationalism

The sentiments peddled by political actors on social media are not coincidental. Rather, they are carefully manufactured texts that convey...

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07 Jul 2023

UP Los Baños

How do Filipino writers represent the experiences of young non-Western readers of science fiction?

Despite the popularity of young adult literature and speculative fiction locally and globally, there is not a lot of critical...

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07 Jul 2023

UP Diliman

What is the optimal position of trees that maximizes walking on urban sidewalks?

Trees can improve the walkability of urban outdoor spaces. Hence, studies have been conducted to examine and elucidate the relationship...

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07 Jul 2023

UP Diliman

Calle Crisologo in Vigan is a lived space and Thirdspace for the people who engage with it every day

Christoph Brumann and David Berliner, in their book World Heritage on the Ground: Ethnographic
Perspectives (2016), ask what World Heritage (WH)...

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Research

Cancer is a leading cause of mortality and morbidity globally. Sex differences in cancer are evident in death rates and treatment responses in several cancers. Asian patients have unique cancer epidemiology influenced by their genetic ancestry and sociocultural factors in the region. In this review, we show molecular associations that potentially mediate sex disparities observed in cancer in Asian populations. Differences in sex characteristics are evident at the cytogenetic, genetic, and epigenetic levels mediating processes that include cell cycle, oncogenesis, and metastasis. Larger clinical and in vitro studies that explore mechanisms can confirm the associations of these molecular markers. In-depth studies of these markers can reveal their importance as diagnostics, prognostics, and therapeutic efficacy markers. Sex differences should be considered in designing novel cancer therapeutics in this era of precision medicine.

The narrative review highlights the existing knowledge and evidence on the molecular roles of sex differences in cancer among Asians. This would serve as basis for research generation with the gains and gaps on the current literature provided. This narrative review tackles the unique genomic and social factors that influence the development of sex differences in cancer among Asians. The study focuses on associations of molecular evidences that can influence sex differences in cancer while also discussing social determinants of health, alongside cancer epidemiology in Asian cohorts. Through this review, a multifactorial and interconnected assessment of existing cancer literature in Asian populations can help develop gaps that future studies may target for specific interventions in the incidence and mortality of cancer worldwide.

Authors: Eric David Ornos, Leslie Faye Cando, Charlene Divine Catral, Elin Paul Quebral, Ourlad Alzeus Tantengco, Ma. Veronica Pia Arevalo (all from the College of Medicine, University of the Philippines Manila) and Edward Christopher Dee (Memorial Sloan Kettering Cancer Center, New York)

Read the full paper: https://www.cell.com/iscience/fulltext/S2589-0042(23)01178-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223011781%3Fshowall%3Dtrue